Pristine aluminum-based metal-organic framework (MIL-53(Al)) as a sorbent shows limited affinity toward bisphenols due to the lack of hydrophobicity in its framework. To overcome this limitation, a dual-linker MIL-53 (Al) with a hydrophobic carbon chain linker was synthesized for the first time and integrated into a pipette tip- micro solid-phase extraction (PT μ SPE) method for bisphenol determination. The parameters affecting the extraction process were optimized by implementing a response surface methodology (RSM) model using central composite design (CCD). Brunauer-Emmett-Teller analysis confirmed substantial increases in pore volume and pore width for the dual-linker MIL-53(Al) (0.74 cm 3 /g; 5.3 nm) compared with pristine MIL-53(Al) (0.17 cm /g; 1.22 nm). This modification boosted the extraction efficiency of dual-linker MIL-53(Al) for bisphenols deter mination, resulting in low detection limits (0.01–0.1 μ g/L), wide linearity (0.033–200.0 μ 3 g/L), high enrichment factors (up to 209), and good precision (RSD ≤ 7.0 %) in tea, disposable cups and containers, instant noodles, PET water bottles.
